Name: The Role of Cytokeratin 19 on Cancer Progression (en Inglés)
SKU: 62755061
Price: 1234.97 MXN
Availability: InStock
Author: Subbroto Kumar Saha
ISBN: 9783659872372

portada The Role of Cytokeratin 19 on Cancer Progression (en Inglés)

The Role of Cytokeratin 19 on Cancer Progression (en Inglés)

Formato

Libro Físico

Editorial

Lap Lambert Academic Publishing

Autor

Subbroto Kumar Saha

Idioma

Inglés

N° páginas

124

Encuadernación

Tapa Blanda

ISBN13

9783659872372

The Role of Cytokeratin 19 on Cancer Progression (en Inglés)

Subbroto Kumar Saha (Autor) · Lap Lambert Academic Publishing · Tapa Blanda

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Reseña del libro "The Role of Cytokeratin 19 on Cancer Progression (en Inglés)"

Studies have reported that interactions between cytokeratins (KRTs) and other proteins initiate signaling cascades that regulate cancer properties. In this study, we found that KRT family genes were differentially expressed in various cancers and the expression of KRT19 was specifically high in breast cancers and significantly correlated with their invasiveness. Moreover, the knockdown of KRT19 (shKRT19) led to increased cancer properties in breast cancer cells via an upregulated NOTCH signaling pathway due to a reduced expression of NUMB, an inhibitory protein of the NOTCH pathway. Additionally, we found that KRT19 interacts with β-cat/RAC1 complex and enhances the nuclear translocation of β-cat. Concordantly, shKRT19 suppressed the nuclear translocation of β-cat as well as β-cat-mediated NUMB expression. Furthermore, modulation of KRT19-mediated regulation of NUMB and NOTCH1 expression led to the repression of the cancer stem cell properties of cancer stem-like cells (CSLCs) which showed very low KRT19 and high NOTCH1 expression. In sum, our study suggests a novel function for KRT19 in breast cancer, which might bear potential clinical implications for cancer or CSLC treatment.