Name: Redirection of th1 and th2 Responses (Current Topics in Microbiology and Immunology) (en Inglés)
SKU: 62103165
Price: 1028.67 MXN
Availability: InStock
Author: Coffman Robert L.,Romagnani Sergio
ISBN: 9783662097113

portada Redirection of th1 and th2 Responses (Current Topics in Microbiology and Immunology) (en Inglés)

Redirection of th1 and th2 Responses (Current Topics in Microbiology and Immunology) (en Inglés)

Formato

Libro Físico

Editorial

Springer

Autor

Coffman Robert L.,Romagnani Sergio

Idioma

Inglés

N° páginas

159

Encuadernación

Tapa Blanda

ISBN13

9783662097113

N° edición

Redirection of th1 and th2 Responses (Current Topics in Microbiology and Immunology) (en Inglés)

Coffman Robert L.,Romagnani Sergio (Autor) · Springer · Tapa Blanda

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Reseña del libro "Redirection of th1 and th2 Responses (Current Topics in Microbiology and Immunology) (en Inglés)"

It has been 12 years since the first proposal was made to sub- divide mouse CD4 I T cell clones into Th I and Th2 subsets, based on their differences in cytokine production, and 7 years since the first clear demonstration of a similar dichotomy among human T cell clones. In the ensuing period, it has been realized that inappropriate development of Th I or Th2 responses are important features of many immunological and infectious dis- eases. Perhaps the first group of diseases to be understood in terms of preferential Th subset activation were allergic diseases (see PARRONC'HI et aI., this volume). Several of the major, co- ordinately regulated, features of allergy, including IgE, eosino- philia and mastocytosis, were found to be stimulated by the T- specific cytokines I L-4 and IL-5 and inhibited by the Th I cyto- kine, IFN-. This suggested that the presence and severity of al- lergic responses reflected the relative numbers of Th I and Th2 cells specific for the offending allergen. Similarly, the very dif- ferent consequences of protective Th I and nonprotective Th2 responses to a number of intracellular pathogens have been re- cognized for some time (see TRINCHIERI and SCOTI, and COFF- MAN et aI., this volume).