Compartir
gpcr signalling complexes - synthesis, assembly, trafficking and specificity (en Inglés)
Denis J. Dupré
(Ilustrado por)
·
Terence E. Hébert
(Ilustrado por)
·
Ralf Jockers
(Ilustrado por)
·
Springer
· Tapa Dura
gpcr signalling complexes - synthesis, assembly, trafficking and specificity (en Inglés) - Dupré, Denis J. ; Hébert, Terence E. ; Jockers, Ralf
$ 3,527.30
$ 5,878.84
Ahorras: $ 2,351.53
Elige la lista en la que quieres agregar tu producto o crea una nueva lista
✓ Producto agregado correctamente a la lista de deseos.
Ir a Mis Listas
Origen: Estados Unidos
(Costos de importación incluídos en el precio)
Se enviará desde nuestra bodega entre el
Lunes 27 de Mayo y el
Viernes 07 de Junio.
Lo recibirás en cualquier lugar de México entre 1 y 3 días hábiles luego del envío.
Reseña del libro "gpcr signalling complexes - synthesis, assembly, trafficking and specificity (en Inglés)"
Main Question: G protein coupled receptors are involved in highly efficient and specific activation of signalling pathways. How do GPCR signalling complexes get assembled to generate such specificity? In order to answer this question, we need to understand how receptors and their signalling partners are synthesized, folded and quality-controlled in order to generate functional proteins. Then, we need to understand how each partner of the signalling complex is selected to join a complex, and what makes this assembly possible. GPCRs are known to be able to function as oligomers, what drives the assembly into oligomers and what will be the effects of such organization on specificity and efficacy of signal transduction. Once the receptor complexes are assembled, they need to reach different locations in the cell; what drives and controls the trafficking of GPCR signalling complexes. Finally, defects in synthesis, maturation or trafficking can alter functionality of GPCRs signalling complexes; how can we manipulate the system to make it function normally again? Pharmacological chaperones may just be part of the answer to this question.
