Name: Effect of antidiabetic agents on hepatic functions in diabetic animals (en Inglés)
SKU: 57355383
Price: 1275.65 MXN
Availability: InStock
Author: Kakadiya, Jagdish ; Rathod, Shivkumar
ISBN: 9786200116260

portada Effect of antidiabetic agents on hepatic functions in diabetic animals (en Inglés)

Effect of antidiabetic agents on hepatic functions in diabetic animals (en Inglés)

Formato

Libro Físico

Autor

Shivkumar Rathod

Ilustrado por

Jagdish Kakadiya

Editorial

LAP Lambert Academic Publishing

Idioma

Inglés

N° páginas

140

Encuadernación

Tapa Blanda

Dimensiones

22.9x15.2x0.8 cm

Peso

0.21 kg.

ISBN13

9786200116260

Categorías

Farmacología

Effect of antidiabetic agents on hepatic functions in diabetic animals (en Inglés)

Shivkumar Rathod (Autor) · Jagdish Kakadiya (Ilustrado por) · LAP Lambert Academic Publishing · Tapa Blanda

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Reseña del libro "Effect of antidiabetic agents on hepatic functions in diabetic animals (en Inglés)"

Type 2 diabetes is a progressive disorder with a consistent and steady increase in HbA1c over time associated with enhanced risk of micro- and macrovascular complications and a substantial reduction in life expectancy. Administration of Streptozotocin (65 mg/kg, i.p) and Nicotinamide (110 mg/kg, i.p) produced symptoms such as hyperglycemia, loss of body weight. Also impaired glucose metabolism and altered hepatic function. The treatment with Metformin (50 mg/kg, p.o) reduced elevated levels of serum AST, ALT, ALP, γGTP and CPK levels which show the protective effect of Metformin (50 mg/kg/day, p.o). This study concluded that Glimepiride (0.5 mg/kg, p.o) alone and combination with Pioglitazone (10 mg/kg, p.o) and Metformin (50 mg/kg, p.o) may show some toxicity in STZ-NIC induced diabetic rats whereas with doses. Treatment with Pioglitazone (10 mg/kg, p.o), or combination thereof Metformin (50 mg/kg, p.o) and Glimepiride (0.5 mg/kg, p.o) showed a significant decrease in diabetic as compared to control nondiabetic rats and diabetic control rats indicate the toxicity in diabetic animal.