Name: Development of Lornxicam Microsponges Gel for Topical Application (en Inglés)
SKU: 57549757
Price: 1056.87 MXN
Availability: InStock
Author: Shinde, Anilkumar ; More, Harinath
ISBN: 9786202519199

portada Development of Lornxicam Microsponges Gel for Topical Application (en Inglés)

Development of Lornxicam Microsponges Gel for Topical Application (en Inglés)

Formato

Libro Físico

Autor

Anilkumar Shinde

Harinath More

Editorial

LAP Lambert Academic Publishing

Idioma

Inglés

N° páginas

108

Encuadernación

Tapa Blanda

Dimensiones

22.9x15.2x0.7 cm

Peso

0.17 kg.

ISBN13

9786202519199

Categorías

Farmacología

Development of Lornxicam Microsponges Gel for Topical Application (en Inglés)

Anilkumar Shinde (Autor) · Harinath More (Autor) · LAP Lambert Academic Publishing · Tapa Blanda

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Reseña del libro "Development of Lornxicam Microsponges Gel for Topical Application (en Inglés)"

The aim of the present study was to prepare microsponges gel formulation containing lornixicam by quasi emulsion solvent diffusion method. Lornoxicam is a Non-steroidal anti-inflammatory drug used for the treatment of various inflammatory diseases. Microsponges were spherical, uniform in shape, between 19 to 136μm in diameter. The production yield, actual drug content and encapsulation efficiency was found in the range of 57.14 0.47 to 88.57 0.799%, 54.78 0.76 to 83.55 0.65%, and 65.73 0.35 % to 95.04 0.42 respectively. The results of compatibility studies FTIR, PXRD, DSC and accelerated stability studies showed that no chemical interaction with drug and excipients. The dermal observation of skin irritation study shows no sign of either erythema or edema after 24 hrs of application. In % inhibition was more in microsponges gel as compare with pure drug gel in anti- inflammatory activity. Formulation of lornoxicam microsponges provides better control over release of drug. This study presents a new approach based on microsponge drug delivery system for topical application.