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Third Generation Egfr Inhibitors: Overcoming Egfr Resistance and Toxicity Problems (en Inglés)
Harun M. Patel; Rahul Pawara; Sanjay J. Surana (Autor)
·
Elsevier
· Tapa Blanda
Third Generation Egfr Inhibitors: Overcoming Egfr Resistance and Toxicity Problems (en Inglés) - Harun M. Patel; Rahul Pawara; Sanjay J. Surana
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Origen: Reino Unido
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Reseña del libro "Third Generation Egfr Inhibitors: Overcoming Egfr Resistance and Toxicity Problems (en Inglés)"
Third Generation EGFR Inhibitors: Overcoming EGFR Resistance and Toxicity Problems reviews current issues relating to the design of reversible and irreversible third generation EGFR inhibitors, highlighting the types of mutation responsible for resistance, and providing different chemical starting points for researchers to optimize and develop in designing the next generation of drugs. Beginning with an introduction to EGFR inhibitors and a review of inhibitors currently approved or in clinical trials, the book goes on to discuss current approaches in the development of both covalent irreversible and covalent reversible EGFR Inhibitors. In addition, mechanisms of resistance to third generation inhibitors, and discovery of fourth generation allosteric C797S inhibitors are explored before a discussion of potential future trends. This comprehensive coverage of the design and development of improved analogues to overcome the problems of resistance and toxicity associated with third generation EGFR inhibitors makes Third Generation EGFR Inhibitors a crucial resource for medicinal chemists, drug developers, and researchers investigating cancer therapeutics. Includes full synthetic schemes of all approved and in-trial third generation inhibitors Highlights the emergence of fourth generation EGFR inhibitors and the possibilities of them overcoming constraints of third generation compounds Provides a structural correlation of third and fourth generation EGFR inhibitors, reviewing both their design strategies and typical anticancer activity
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El libro está escrito en Inglés.
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