Don Tillman is a socially challenged genetics professor who's decided the time has come to find a wife. His questionnaire is intended to weed out anyone who's unsuitable. The trouble is, Don has rather high standards and doesn't really do flexible so, despite lots of takers, he's not having much success in identifying The One. When Rosie Jarman comes to his office, Don assumes it's to apply for the Wife Project - and duly discounts her on the grounds she smokes, drinks, doesn't eat meat, and is incapable of punctuality. However, Rosie has no interest in becoming Mrs Tillman and is actually there to enlist Don's assistance in a professional capacity: to help her find her biological father. Sometimes, though, you don't find love: love finds you...