metastasis to bone is a common event in cancer. however, due to the skeletons unique structure, exploring how cancer cells target the skeleton and interact with the bone microenvironment is challenging. the biology of skeletal metastases covers areas that are important to both clinicians and basic scientists seeking an enhanced understanding of mechanisms of skeletal metastasis, as well as descriptions of cutting edge therapies for skeletal metastases. both increased efforts by many investigators and advances in research methodologies have provided a wealth of information in the area of skeletal metastases. the biology of skeletal metastases brings together experts to describe these many advances. this book provides background in basic bone biology and biology of metastasis for novice investigators and highlights many advances in this challenging field for the experienced investigator.