This book offers a comprehensive reflection on the existential condition of the 21st century. A visionary introduction to existential posthumanism, it takes the form of eight meditations. This posthuman journey of self-inquiry engages with a wide range of knowledge and wisdom: from the Paleolithic times to the futures of radical life extension, from multi-species evolutions to the rights of Nature, the Anthropocene and the rise of Artificial Intelligence. The book declutters the habit of being human. Letting go of the need for anthropocentric mastery and species-specific ambitions, the reader emerges regenerated. The manifold paths of posthuman self-realization reveal that we are all co-creators in the existential unfolding: our lives are our ultimate works of art. The Art of Being Posthuman is a self-help guide to navigate our brave new world.