Using an evidence-based perspective and key concepts from the Occupational Therapy Practice Framework, this guideline provides an overview of the occupational therapy process for adults with traumatic brain injury, including definition, epidemiology, stages of recovery, referral, evaluation, and interventions throughout the various recover phases. This publication is designed to help occupational therapists and occupational therapy assistants, as well as individuals who manage, reimburse, or set policy for occupational therapy services, understand the contribution of occupational therapy in treating adults with TBI. This guideline also can serve as a reference for parents, school administrators, educators, and other school staff; health care facility managers; education and health care regulators; third-party payers; and managed care organizations.