Lizzie, age eleven, does not let her wheelchair get in the way of her curiosity. After she is partially paralyzed in a diving accident, Lizzie and her single mom are starting life over in a small town in Florida, where Lizzie's thirst for knowledge and adventure makes her some unlikely friends and gets her into some sticky situations. Resilient and precocious, Lizzie has a passion for learning new words (especially those with Latin roots) and a propensity for finding trouble, which is how she ends up stumbling upon criminal activities involving seedy characters, beautiful golden monkeys, and murder.