Bone Game is a murder mystery on a grand scale. Cole McCurtain, a mixed-blood Indian professor of Indian Studies at Santa Cruz, California, is haunted by dreams dating back to events of Spanish California. Images of a Spanish priest murdered in 1812, a rearing grizzly bear, and a black-and-white painted Indian who offers bones in his extended hands come at a time when dismembered pieces of a young woman are washing ashore in 1993. The dreams become increasingly urgent as the murders become more frequent, and Cole’s family and friends gather to help-including Choctaw relatives who travel west from Mississippi because "this story’s so big, Cole sees only a little bit of it."