A&C meet Frankenstein is in production and there's strange doings afoot at Universal: a phantom arsonist and an escaped Nazi scientist are on the loose and will kill to keep their secrets. Karloff and Rathbone are keeping a secret from Lugosi, and he doesn't like it one bit! Lugosi enlists the aid of Lou Costello as his Watson. They soon cross paths with wolf man Lon Chaney, Jr., monster man Glenn Strange, and mysterious beauty Lenore Auber. It isn't long before Lugosi and Costello uncover the shocking secret behind...the House of Doom.