this volume constitutes the proceedings of the 10th international conference on artificial intelligence and soft computing, icaisc?2010, held in zakopane, poland in june 13-17, 2010. the articles are organized in topical sections on fuzzy systems and their applications; data mining, classification and forecasting; image and speech analysis; bioinformatics and medical applications (volume 6113) together with neural networks and their applications; evolutionary algorithms and their applications; agent system, robotics and control; various problems aof artificial intelligence (volume 6114).