In this issue of Gastrointestinal Endoscopy Clinics of North America, guest editor Dr. Tamas Gonda brings his considerable expertise to the topic of Advances in Diagnosis and Therapy of Pancreatic Cystic Neoplasms. Some estimates predict that over 2% of all patients 65 and older may have a pancreatic cyst and over 5% of those who undergo cross-sectional imaging will be found to have a cystic lesion. This issue provides an overview of current diagnostic approaches and emerging data on some of the novel imaging and biomarker strategies that improve accuracy. Top experts cover current guidelines for diagnosis and surveillance of pancreatic cystic lesions, high-risk individuals, the decision-making process, and much more. Contains 12 practice-oriented topics including burden of new pancreatic cyst diagnosis; next generation of radiologic assessment for pancreatic cystic neoplasms; endoscopic therapy for pancreatic cysts; surgical innovation for cystic neoplasms; and more. Provides in-depth clinical reviews on advances in diagnosis and therapy of pancreatic cystic neoplasms, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.